Hepatitis C :: Relapse After Daclatasvir And Sofosbuvir Treatment
Mar 23, 2016
I have just found out that my father who has finished his 12 weeks treatment (Sofosbuvir + Daclatasvir) about a month ago has had the virus relapse. It was undetectable in all previous tests, but the recent test showed it. I was wondering if anyone can point me to the right sources, perhaps specialists and experts we could contact as in Poland (where we live) there doesn't seem to be enough information. We are not sure what to do next... He has had this horrible virus for more than 10 years, we were so happy to have cured it! But refuse to lose hope and want to keep fighting!
View 4 Replies
Advertisement
I'm looking for advice. My 60 year old father (who has had HCV for more than 10 years; previously treated with Interferon but bad side effects) finished his 12 week Sofosbuvir+Daclatasvir (considered same as Harvoni) treatment a month ago. Already first tests after 2 weeks showed virus was Undetected, but yesterday he received his most recent results and he has a relapse of the virus. He is genotype 1, fibroscan result 4 (close to final stage). He is based in Poland and I'm not sure if our doctors are fully informed of the new generation medications and HCV itself.
Is anyone able to give us any advice? We are pretty desperate and my dad is just so depressed as he thought he finally got rid of the virus (he got infected while on an operation in a public hospital) and now it is back...
Are there any specialists that you are aware of I could possibly get in contact with?
View 1 Replies
Does anyone here relapse after harvoni treatment?
View 3 Replies
I wonder if any readers have taken sofosbuvir. What is your experience? Mainly, how did it get financed?
I would love to get rid of my Hep C, but wonder how anyone can afford the new treatment.
View 1 Replies
Does anyone know what the possibility of relapse is if you are und at 4 weeks post treatment?
View 8 Replies
I have been using oxycodone 30's for 2 1/2 years. The dose I was using was up to 9 a day I finally reached a breaking point and decided to get clean I started out with suboxone 8/2 3x a day then I stepped down to gabapentin 400mg 3x a day, clonidine 0.1 mg a day and baclofen 20mg 3x a day. I have been on these meds for 2 months and as much as I don't like it I relapsed 3 weeks ago now I went back on my meds but I'm still getting detox symptoms when I'm off of them. I get headaches runny nose over heating aches and pains but not as bad as if I was coming start off Roxie's. now my question is how long does it take for me to go back to normal or even if ,
View 2 Replies
I have been diagnosed with Hep B. I was admitted to hospital with exceptional readings (ALT >4,000, bilirubin 180, all pho 162, gamma get 417, AST >2,500). I've been given various drips and the numbers are coming down. ALT has now halved. In addition to the drips I was also put on Viread.
My physician was concerned how my immune system was attacking the liver and between all treatments, in three days the readings are coming down. My jaundice is going and my urine now looking paler (almost normal).
Given the symptoms indicate a severe acute response to infection, does this suggest my body will put up a good fight to rid itself of the virus. Also, is there a risk Viread could actually lead to my body not developing the antibodies? I've read the following study, which suggests Viread can be highly effective in treating severe acute Hep B and also assist (or at least not inhibit) the development of antibodies.
View 3 Replies
My sister in law, a very good doctor who has always given me sensible advice when I have asked, suggested I get my CRP checked. CRP is apparently a marker for inflammation in the body, although lupus and rheumatoid arthritis do not always trigger it.
I know I sound like a broken record, but I really think a lot of post-interferon syndrome can be explained by body-wide inflammation - chronic fatigue arises from an inflamed brain; psoriasis is inflamed skin; arthritis is inflamed joints; fibromyalgia is inflamed muscle tissue; vasculitis is inflamed blood vessels, etc.
Our immune systems were amped up by the drugs, and they never settled down again quite right. The drugs induce autoimmune disorders that can effect every system of our body.
If I eat bagels and cream cheese (I love bagels and cream cheese) for two or three days in a row, and throw in a pizza, all my inflammatory symptoms get worse, including depression and fatigue. My ankles swell. My psoriasis gets worse. My joints start aching worse. My fingers start trembling and twitching spastically. I had nothing like this before treatment.
So anyway, if anyone cares to follow this theory, it means eating a non-inflammatory diet - no pizza, no fast food, skip the sugar, read In Defense of Food. The more you want to live, the better you will eat. If anyone cares to follow this theory and is having their blood drawn anyway, be sure and get CRP checked. My sis-in-law says it's very inexpensive test. I'd love to hear of any correlation or thoughts on this subject.
View 20 Replies
When I first began treatment with pegasys in january 2014, GGT was 60 (normal max is 35), ASAT 51 (normal max 35), ALAT 76 (normal 10-40), LDH/Bili/CK all within normal range. With pegasys, a few months later down the line, the values continued to go higher. At their highest, GGT 223, ASAT 116, ALAT 156, LDH 274, Bili/CK remained within normal range.
At the beginning of the treatment, Hep B ie/ml was 2400. Four months later, it became 2600. When I was shifted to tenofovir/Viread three or months after beginning treatment since pegasys wasn't solving the issue, the ASAT, ALAT, LDH came back down to normal levels quite fast. So I have been on viread ever since.
10 months after beginning treatment, Hep B ie/ml was down to 1800. In 2015, it was less than 150. Hep B Dna was undetected by May 2015. I get regular blood tests every three months since the start of the treatment.
Yesterday's blood test showed: ASAT 36 (normal max 35), ALAT 38 (normal 40, but having checked past blood tests, it seems in the last few months it has been gaining one or two points steadily so this is worrying me), LDH and Bili are normal. The bad news: Heb B DNA detected...and IE/ml was a whopping 3400!!!! More than when I started started treatment!
The first thing I was asked was whether I missed a dose of viread. Answer is no. However, I have had incidents where I did forget to take it on time, but it has never exceeded 5 hours (still, I know, it's a huge gap). Not a lot of times, but I find that I am beating myself over this now, as it may be the reason I am having a viral overload and maybe made the virus resistant to viread.
Since taking viread, I have experienced and continue to experience extreme muscle pain (I ended up in the hospital once when diclofenac failed me and I needed an extra morphine shot to get relief). I am continuously tired, some days it is a real struggle to move (feels like going through mud - heavy body, wanting to simply just crash on the floor). I have not had a pain free day in the last two years and worse, kidney stones! I am already prone to them, but I can't get over the suspicion that Viread has ensured I have a stone that needs to be taken out each year.
I've read that viread is one of the best treatment there is (hardly any side effects, probability of virus resistance low) so my latest blood test is worrying me no end. I am not due for another DNA test until 6 months later. I've also read that ASAT and ALAT values can increase and it's not necessarily liver related (I think my ongoing and increasing muscle pain is reflecting higher ASAT and ALAT values but who knows?!?).
My doctor says that as long as those values remain within normal range and not in the hundreds, it should be ok. But there is this unspoken thought that I am in deep trouble if the DNA continues to manifest and my liver enzyme values continue to increase. My liver scan in 2014 has me a point JUST before entering cirrhosis stage. I can't help but think I may have actually crossed that line already (the cassandra in me speaking) though I am assured that viread treatment tends to pull back the damage.
My question..Has anyone ever experienced a viral increase during the viread treatment, and if so, was it temporary, or was viread stopped? I am not sure how to read/interpret this ie/ml, but the fact that it has increased can't be good news at all.
View 6 Replies
I am currently on Harvoni for my Hep C and I wanted to ask has anyone had the virus return or a unsuccessful treatment?
View 2 Replies
I'm finishing up my last two weeks of treatment on Harvoni and wanted to know some feedback from people about there current health situation such as achievements of SVR,and side effects during or after treatment?
View 6 Replies
Its been Since Tuesday PM since I finished my 12 weeks and I still feel like I am on it.
View 3 Replies
I just received my first shipment of harvoni in the mail. My dr is starting me on a 12 week treatment plan. I was excited to hear about this new medicine that has little side effects and a high cure rate. But now that I actually have the medicine in my hands, I'm extremely nervous. If there is anyone out there that has tried harvoni can you please share your experience?
View 3 Replies
I am not going to take herbs with my S/O treatment. I started treatment three days ago. Take both pills at the same time right after dinner - no side effects whatsoever or any unusual filling so far.
Let me know what is the reason to stay away completely from sun? Also if this is OK to take general vitamins and supplements during the S/O treatment?
View 3 Replies
One of my friend has Lupus Erythematosus and needs a liver transplant, but during the blood transfusion, she got HCV. She wants to take daclatasvir or sovaldi(sofosbuvir) for curing HCV, but is worried that daclatasvir or sovaldi(sofosbuvir) would have side effect that is bad for Lupus Erythematosus. So I wonder if Lupus Erythematosus patients take daclatasvir or Sovaldi(sofosbuvir) for curing HCV? Were there any successful or failure previous examples?
View 1 Replies
Just found out I have hpv...cervicitis...and just had a relapse of ebv. Been 3 months of hell what could be causing my body to all of a sudden be reactivating viruses? Hpv is new but I'm sure I was exposed 10 years ago and I got ebv when I was 15. My blood work was mostly normal I have high ALT (SGPT) Levels at 40
I have high platelets 534
A high count for EBV which is mono. ENT wasn't concerned about anything else besides the mono. But that it's not active anymore. Still have awful symptoms my throat hurts feeling sharp pains in my abdomen. I have a low risk strain of hpv everything came back normal with my biopsy and colposcopy except that i have an inflamed cervix. my symptoms won't stop! !! Feels like even more is going on since it just seems like my body is pulsating diseases through my veins. It's awful. It hurts and it's uncomfortable.
View 47 Replies
A few weeks ago my bf noticed some bumps in his pubic area. He went to the dermatologist and was diagnosed with molluscum contagiosum, which is thankfully not that big of a deal! He got his treated with cryotherapy. Around this time I noticed a few bumps and because of the area they were in, went to an OBGYN for treatment so my bf and I don't keep spreading it to each other. The OB GYN agreed that they were also MC bumps and lightly scraped each one, then applied an acid treatment. That was a few days ago and while the bumps are mostly gone, the skin surrounding each one is dark and almost looks like a scab in color. Is this normal post acid treatment?
View 1 Replies
Has anybody ever had a VN relapse as it seems i have after a year is it possible or have i just picked up another virus?
View 6 Replies
I recovered from stg 3 Sarc (in lungs, lymph, joints, sinus) 13yrs ago, after 5yrs of illness and 2yrs of steroids.
I now have Erythema Nodosum (sp?) - red painful bumps on lower legs.
Research suggests that 'EN' is associated with a specific version of Sarc, Lofgren syndrome, which is usually resolves quickly and without treatment.
I'm scared to go to the Dr, as I don't want to face the tension & round of tests to exclude a Sarc relapse. It's not something I want to go through again...
I wonder if it's very likely for a relapse to come with a whole new presentation of the Sarc? Or is it unlikely to be sarc, as I never had EN the last time?
Does anyone have any experience or advice which may help me decide what to do?
Best wishes to all who are currently battling with their Sarc, I truly understand your pain and your exhaustion. I was not expected to recover last time - but I did.
View 4 Replies
About 4 years or so ago I had a relapse in the left upper leg and thigh. Recently I have been under quite a bit of stress... since this.morning I woke up with more severe pain in left that is now going down my whole leg into my little toe and the toe next to it... I have been taking 7.5mg vicodin twice daily since the last relapse that helped me out alot to function.... I was transferred to a pain specialist who said that is was not my ms cause this problem ( I have had 3 docs) tell me it was due to my ms relapse previously now I am scared and am lost as to what to do. As the day has progressed on I can barely even walk or put weight on my left leg?
View 4 Replies
I was diagnosed with PMR July 2012, with ESR 62, put on 15 mg Pred, 11 days passed before I was free of pain. 1 month later Doc reduced me to 10 mg. ESR than 10. Then later to 7.5mg and finally to 2mg by Oct 2013. Relapse started Dec 2013. Doc started to increase Pred. to 6mg.but pain persisted so Doc increased me in stages to 15 mg, (pain persisted) so Doc said go to 20mg or even 30 mg if pain still persists. Pain is persisting. Meanwhile, a full blood test was done and all came back normal, ESR now 12. Just to complicate matters, there was a moment 12 days ago when for 4 days I mixed up my tabs and was taking only 4 x 1mg, when I should have been taking 4 x 5mg. I am now on 3rd.day at 30mg. but pain still persists.Does anyone have any comments please?
The only other query on my mind is the fact that I was given a Pneumonia jab 3 weeks ago, could this play a part.?
View 19 Replies
