Transplants - Sirolimus :: Creatinine High - Level Is ~1.7 For Last 1.5 Year


Sep 20, 2014

I have completed 3yrs after liver transplant. My creatinine level is ~1.7 for last 1.5year. Prograf dose is reduced to 0.5mg BD, and tac level is 6.3. Mycophenolate can not be used because it causes leucopenia.


Doctor is thinking to switch to Sirolimus. But with Sirolimus I see this warning.

The safety and efficacy of Rapamune (sirolimus) as immunosuppressive therapy have not been established in liver or lung transplant patients, and therefore, such use is not recommended [see WARNINGS AND PRECAUTIONS].

Liver Transplantation – Excess Mortality, Graft Loss, and Hepatic Artery Thrombosis (HAT)"

Do you think it is safe to use sirolimus?

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