Methotrexate And Alcohol


May 11, 2014

I've begun taking a dosage of 10mg of Methotrexate and that was on 10 of May, I have a party to attend on the following Friday the day before my next dosage. I know that alcohol is not suggested on Methotrexate and up to two drinks is permitted but it will be a day before my dosage so that means i've only taken one tablet, there wouldn't be enough in my system to start inhibiting it would there? I plan on drinking more than two standard drinks and I need some help to know if I there will be any drug interaction producing liver problem or illness.

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Hi, so i've read here multiple times that although you should not be drinking while on methotrexate, people have found that their alcohol tolorance has gone way down. Has anyone else had the opposite effect? 

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And what would you say your side effects are? And how good is the drug at easing your condition?

For me, and I have been taking it for around 2 years now. My condition has improved greatly. But, my elbows and wrists are still not fully flexible, I was tempted to ask my GP for some 'one off' steroid injections to ease the swelling in some of my joints. But other than that awesome.

I do get tired though quite easily, particularly the morning after the methotrexate intake. Folic acid probably eases the side effects though, which I take the following day.

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Polymyalgia Rheumatica :: Prednisone Vs. Methotrexate?

It's now two years since first diagnosed with Polymyalgia Rheumatica and the first Prednisolone which was like a miracle and I guess still would be if I 'overdosed'. Currently well stuck at 10 mg there seems no way forward. I've tried the slow taper but the first day I drop there is a reaction so I had decided to just take a quiet view and stick at 10mg until the new year and then try the slow taper again.

I'm not uncomfortable at this level and it does not worry me to stay at this level.

But, the Hospital called today as there was a cancelation and I was overdue to see the Consultant. Chatted over my position and he expressed concern that I had become steroid dependant, something that can happen after two years. Whilst the dependency was not something that concerned him in itself it did however at the 10 mg level. Get to 5mg 'ish and that would be more acceptable.

So he wants me to go on Methotrexate, starting with a three month course running alongside the 10 mg of Prednisolone. This is to be closely monitored by a 'specialist' under one if the consultants (can't remember for what) and will mean blood test one or twice a week. Then after another Rheumy appointment in three months a decision will be made to start lowering the Prednisolone.

The whole thing seems horrific, especially as I have just noticed in an article on this site the following 'There is little evidence for the efficacy of steroid-sparing agents - eg, methotrexate or anti-tumour necrosis factor agents. Methotrexate is the most commonly used corticosteroid sparing agent.'

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Polymyalgia Rheumatica And GCA :: Methotrexate Experiences?

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As I've read here many MTX patients have been on this drug for months if not years. My Dad was on this drug for only five days.

Here is some advice for everyone on this drug:

> Please everyone always ask for a consumer information pamphlet and be aware of the side effects.

> Even if you feel fine don't ignore any side effects

> Hospitals don't check for MTX levels in the blood - if you find yourself in Hospital ask them to test the levels.

> Be aware of leucovorin therapy ; known as 'rescue therapy' (this is administered if you have suspected MXT poisoning)

> Always follow the directions from a rheumatoid arthritis specialist or dermatologist or oncologist - not a general practitioner

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Has anyone had a repercussion of not using any of these tablets where it's been prescribed along with MTX?

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I almost feel a fraud here as the docs say I don't have PMR.

On the recommendation of this group I requested a 2nd opinion. I asked to be referred to see Professor Bowman at The QE Birmingham.

Today was my big day. Well the Prof was lovely. He listened really well, gave me a good examination and is following up with loads more blood tests.

I was also treated to xrays on my chest, hands & feet.

Now the downside (again) he went over all my blood results from the last 9 months and said that every result pointed to PMR. But bigggg BUT,

he doesn't feel he can say it is as I am too young! (44) I certainly don't feel to young when I am trying to get out of bed and get moving in a morning.

I have been on pred for few months now after begging my GP. Then refusing to leave the surgery until they listened. My GP agreed to a trial. Base line bloods for ESR & CRP 6 weeks on pred at 15 and then more bloods. Results were amazing and my bloods came back almost within the normal range. Good news my GP has since said I do need steroids.

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He wants me to come off pred using the dead slow method and wants me to start another drug.... Either Methotrexate or Azathioprine. I get tp choose.

So my lovely people have you had any experience of these drugs?

Which one would you choose?

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