Prostate Cancer :: Hormone Therapy Side Effects - Casodex (man Boobs)


Aug 14, 2015

I have been on hormone therapy since May '06 (9 years) With a PSA of 28, I elected to do daily hormonal therapy along with Eligard injection every six months and have been EXTREMELY lucky that it continues to keep the beast at bay. (Undetectable) I feel fine but I have "man boobs" from the use of Casodex for so long and they are somewhat embarrassing. In a effort to reduce the size and tenderness, the Uro agreed to allow me to reduce my dosage in half and the last two checkups showed PSA still holding at "undetectable".

My question is this:

1. Has any members had this issue and Corrected it?
2. If I have orchiectomy surgery, would I STILL need to take Casodex to keep the PSA down?

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 Here are my own observations at week five into LH hormone therapy.

> After a faltering start I settled into three or so mild hot flushes a day with some at night.

> The worst part for me is that shortly after the onset of a flush my memory is impaired and logical thought becomes confused. I could live with the fuzzy feeling in my head if that was all. This impairment lasts about one hour after the flush subsides. So I cannot do much sensible work or play the piano without making a hash of it and frequently forgetting how to continue the piece I am playing.

> I have found the advice to keep cool helpful. So I wear lighter clothes than formerly and try to keep a feeling of being slightly cold. I don't like that but it is better than a flush.

> I have accepted the advice of many that exercise is helpful. Amongst other benefits it is held to assist in limiting hot flushes. So in addition to my afternoon stroll with my wife (I.5 to 2 mph) I now take two brisk walks a week on my own. (3 to 3.5 mph - I used to manage over 4 mph). Again picking up on advice relating to hormone treatment I have added home devised power exercises with chest expander spring and hurrying up and down the stairs six times in succession. Plus, pelvic floor exercises in anticipation of radiotherapy.

> I found that stress, warming exercise excluded, frequently brings on a flush. 

DISCOVERY or just something I had missed.

> I have found that if during a flush if I do some exercise that I know from experience will be enough to warm me, when I stop I cool down normally and so cut short the flush. (I must cool down. If I stay warm the flush takes off again within a few minutes.) My flushes normally last about 90 minutes. For me the effective exercising is

>> six  times rapidly up and down stairs.

>> five minutes brisk walking

> If I do this exercising within about 60 seconds of the start of the flush I avoid the memory and logic problems. (Any delay and the problems last the usual hour after the end of the exercising / flush. )

Does anyone use a similar "cure" for a flush? Does it work for anyone else? 

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Bone scan normal.

Age 60. Generally healthy.

I have been advised surgery or hormone therapy for three years together with radiation.

The surgeon preferred surgery as did the consultant who would have been in charge of hormone therapy.

I think their logic was that surgery gave the greatest chance of 100% cure.

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My 65 yr old brother was diagnosed with PC last December and has been receiving hormone therapy injections since then.

He recently commented that he’d lost about a stone in weight since January and I started worrying.  Since doing some research on the net, I’m still worried as I can only find weight gain mentioned  as a common side effect of this therapy. 

The only mention of weight loss is in connection with other symptoms such as loss of appetite due to sickness, bone pain etc in more advanced cancer.  So far he hasn’t had any of those and his only symptoms, apart from a few hot flushes, are an increased need to pee and taking longer to do so.  He hasn’t been on a strict diet and, although he’s been more careful in what he eats for several years, he hasn’t been able to shift much weight until now.  He still has a healthy appetite.

I don’t know whether we’re worrying unnecessarily or whether he should have a word with the doctor.    

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I honestly did not realize for many years how helpful it was with these symptoms. Of course, for me, these symptoms didn’t really manifest themselves to any significant degree until I reached actual menopause. Once we reach menopause (12 consecutive months without a menstrual cycle), our estrogen production in our body has decreased significantly. Hence, vaginal dryness, brain fog, short-term memory issues, and oh, the insomnia!

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I recently looked into getting help through the Internet for hormone replacement therapy.

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