Blood Vessel :: Drug-induced Thrombocytopenia?


Oct 7, 2015

My general/gastrointestinal surgeon request a complete blood test as a pre-surgery exam in order to perform a fundoplication, to solve a gastroesophageal reflux disease (GERD) that I've had for three years. My condition is not responding to high-dose proton pump inhibitors, diet or lifestyle changes, because I have a hypotensive lower esophageal sphincter and my esophagus peristaltic rhythm is lower than normal.

I've been taking 80 mg (2x40 mg) of esomeprazole + 20 mg (2x10 mg) of domperidone daily for about a month, and during the day before the blood exam, 900 mg (3x300 mg) of ibuprofen in 8 hours interval, as I was having a muscle pain on thighs due to heavy exercise on weekend without warming up properly. The pain has since completely gone.

I did the blood exam yesterday, on Tuesday at 8:30 (I took the last pill of ibuprofen on Monday at 22:30), and receive the results today. I explained to the nurse who drew my blood that I took these medicines. My platelet count was low (thrombocytopenia), and I suspect due to either the PPI drug or ibuprofen.

As you might know, the platelets are essential in blood coagulation process after a an injury (such as a surgery), which is something the surgeon needs to be sure that I don't have coagulation problems and will have a hemorrhage during the procedure.

The normal platelet value is between 150,000 and 450,000, but in my result was 143,000. The Platelet Distribution Index was 72,7%, when the normal values should be between 25 to 65% according to the parameters in the result. Mean Platelet Volume is 10,1 fL (femtoliter), which is within the normal range (7,2-11,1) fL. Every other coagulation parameter is normal, along with HDL, triglycerides (in optimal or normal range), etc.

All my previous blood tests resulted in normal values of platelets amount, but I wasn't taking any medication when I underwent the complete blood test. I read the package inserts for esomeprazole and ibuprofen (or any other NSAID), and thrombocytopenia was among the possible adverse effects. I think that the ibuprofen is the main culprit, I only took it because I had a major muscle pain (due to extreme fatigue) that really hurt, but I didn't know it could interfere with the platelet production. As I said, I told the nurse i took these medicines.

I don't know if the surgeon will think that I have some blood or vascular disease (which I don't believe, as all my previous blood exams were normal and I don't have any symptoms) and will not do the procedure on me. Should I ask him for a 2nd blood test to see if platelets levels will get back to normal? Or he will take the fact that I've been taking 3 medicines into account? and consider this a pretty much normal or expected result?

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My memory, both long term and short term, is shot. I cannot remember names, stories, facts, and many things that were easily retrievable only a few months ago.

Basically, from June until recently, I had major sleep problems. My primary doctor was reluctant to prescribe any kind of sleep medication. Also, I had poor sleep hygiene, and continued to smoke cigarettes and eat an unhealthy diet. Ultimately, I did not sleep for about two months. At most, I would get 2 hours per night.

At the same time, out of desperation, I started to abuse zzzquil. I would take 2x to 2.5x the recommended dose. All things considered, I am a large guy, at about 250 pounds. Still, in the beginning, that dose would afford me 6 hours of sleep. A couple months later - none.

If I was not taking zzzquil I would try melatonin with no results. If not melatonin, I would drink high quantities of alcohol (whiskey, straight up).

I had to quit my job recently, which was an easy one, as I could not focus upon any kind of work. I cannot remember numbers and figures for minutes after I have seen them. Even writing this post is very difficult.

At this point, I pace around my parent's house, chewing ice cubes, driving them crazy, mumbling to myself about how much I suck at life. At one point I was a smart guy - now I feel like a 95 year old.

My parents, my friends, people in AA, my general practitioners, everyone, say that I can make a comeback and that this damage is reversible. I thought that brain damage was irreversible? I cannot afford nor even get a referral to see a neurologist.

Before this summer, I was a chronic alcoholic and marijuana abuser, even for a time while on antidepressants, and have been incredibly irresponsible. My life is a current agony. What should I do? Should I believe that my parents and those around me are correct, should I give up as I am too broke to afford treatment? I am clueless, feeling hopeless, stupid....

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I have read and studied so far it appears I have developed a drug induced anxiety disorder.

This happened 3 weeks ago when I smoked cannabis for the first time.

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I am scared that this will last forever.  I was prescribed citalopram 10mgs but i haven't taken this as I have faith i can get cured without it.

I also cannot imagine suffering from the side effects of citalopram as what I am experiencing is already horrifying.

Does this last forever?  What can I do to cure it?  I have no previous history of mental illness. I also am quite chubby 66kgs so could it be the effects of the THC in my system?  as I said i feel better than when it started but i am losing hope.

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Drug Induced Irritable Bowel Syndrome

I'm 65 this August, and for the past 26 years have had FMS and Osteoarthritis, progressing into a host of other auto immunes in the past 2 years along with moderate elevated cholesterol, osteoporosis, vertigo, Meniere's. And have had some run in's with a few doctors and PT people who are in it for the money, not patients health. That said the issue is Big Pharma and FDA along with doctors who push the drugs on people. We have all heard the TV ads for a lot of these drugs. Heed those ads. Crestor was supposed to be the drug of last resort for cholesterol but through a multi-million $$ ad campaign they are now number 1, and have the most side effects of all the cholesterol drugs on the market

I react to nearly any drug that says GI, muscle or vision. Not little mild side effects, nor the kind that send you to the hospital because you have had a acute reaction. But bad enough it is worse than the disease it is treating, and make you wish you could die and get out of the misery.

Thanks to their drugs starting with osteoarthritis ones, progressing into estrogen's my GI system is a wreck and I live on 80mg of Nexium daily. It is the only one I can take without other major side effects. Yeah a drug that will work for me.

Not all of us are drug sensitive but those with FMS or other auto immunes tend to be more sensitive to drug side effects.

So it brings me to the question how many of us suffering from IBS, and don't even realize it might be caused by one of your prescriptions. Few people take the time to read up on the drugs their doctors order, to much faith placed into a person who has to little education on those drugs they are ordering, they know what the drug reps tell them and what the TV warns about. And that is what they hope for. READ ABOUT THOSE DRUGS, dig into the blogs too, as that is where you will find the truth about the side effects. Take it all with a grain of salt not as gospel. Ask your self how this drug is effecting my system.. And do not take more than 1 new drug at a time it muddles your monitoring, give yourself time to monitor what it does to your body.

Some pills will react right away others may take a month or two to turn on you. Request a copy of your medical records, you would be surprised at how inaccurate they are. Mine say I've had my adenoids and tonsils removed...duh, my first surgery was a C section in 1972, unless you count the removal of wisdom teeth that came in side ways. Plus that I am on a ton of drugs I tried and rejected because of side effects, but my records still show me taking them to this day. And I give my PCP a list of side effect drugs each 6 months I see him, yet few get on the side effect list.

You must be informed well not only on the health condition you have but on what drugs they use on you to treat it and what they can do to you.

With FMS the two main drugs are Lyrica and Cymbalta, both highly riddled with side effects, Cymbalta numbs your brain, as if FMS did not do that badly in the first place. Lyrica can cause more pain, stomach issues, joint pain and a ton more. It's side effect failure rate according to my pain management doctor is 50%, now I'm not the brightest bulb in the pack but 50% failure is way to high for the FDA who is supposed to police these drugs to leave a drug on the market.

What truly happens is you complain of side effects to your doctor, HE does NOT report them to the FDA, that is YOUR job..and good luck there, there are NO Humans at the Bad Drug Hot Line. So you are given a different drug, and the roller coaster goes on until they find one you tolerate better. Still with the side effects unreported.

Then there is nutrition, when you are told to go on cholesterol lowering diets, what vitamins and minerals that are necessary for your health has been lost. Your Thyroid is the main gland of your body, it only requires a few mcg of Iodine, eggs, dairy and meat are the main natural source. Sea Salt does NOT contain Iodine. Nor is it white, it is light pink, lt gray or gray. Many of us are on salt restricted diets to boot. Ever wonder how many hours of nutrition training your doctor has had? NOT much. Because other than telling women to take Calcium and D, they do not bother to tell you that you have to replace the nutrients the diets they insist on take away or it will lead to other health issues in the long run.

Vitamins or minerals have to my knowledge never killed or gave cancer to any one, but big Pharma's drugs do!

You might think I am anti drugs, no, wrong, they have there uses, but YOU the consumer must take it upon yourself to become EDUCATED about what they do and watch your body's reactions to them. Doctors are not gods, their words are not the gospel either. USE YOUR BRAIN, do your home work on the drugs and your disease.

READ, LEARN, GET INFORMED!

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I appear for the defence , M'Lud. 

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I did have difficulty getting up in the morning and feeling groggy after that, but those lessened with time. I take the minimum mirt that allows me to get to sleep - about 11 mg,  and I think that keeps the side effects down.

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