Depression :: Mirtazapine -> Pregabalin -> Lofepramine - Nothing Worked

Have lost lots of time on medication that has not helped this year. From start of year have had depression/anxiety issues, for a time was on Mirtazapine, and then also Pregabalin. Things got worse and dose was upped of Mirt, progressively until we tapered me off it and moved me on to Lofepramine. The Preg/Life seemed to interact with negative side effects physically and I ran down the Preg, with no negative impact. So for a while was on Lofepramine only and I seem to have neither improved nor got disastrously worse, but have still really found the negative feelings a challenge. Sleep was patchy, but slowly improving, mornings though not as bad as when on the Mirt were still slow and tricky. I'm condensing months of this here. Sorry if its a bit of a brief summary.

The upshot was for a few weeks I was reduced down to half a 70g Lofepramine, and although things were still difficult my judgement was they were not particularly doing much to help step up from the mood I have had for quite some time now. So for 4 days I stopped it altogether. Now I have really struggled the last 2 mornings and have often been under a cloud. I think partly this could be just paranoia about stopping, but I gave in and took the decision to step the Lofepramine back up again and started on 70mg again today. At this point I am not really sure what to do and maybe need to reassess again with the doctor. Its probably fair to say Lofepramine may have helped more than anything else I have tried this year but I am not convinced it does enough.

So considering options. Have not yet gone down the road of an SSRI, so Sertraline, Escitalopram, or what or maybe I should have stayed off Lofepramine for longer to get a better view of whether I am just getting over some withdrawals from it and needed to persist.