Hepatitis B :: ALT Increase After Stopped VIREAD 3 Weeks


Apr 2, 2016

I just had my second child 7 weeks ago. I stopped taking VIREAD FOR 3 weeks after gave birth because of breastfeeding. But ALT was increased to 53. Then I continue to take VIREAD but now the ALT is still 53.  I remember this medicine can control liver function very quick when I started to take it years ago. is it possible the medicine doesn't work on me anymore? anybody can explain?

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After 1month of viread, my alt increased from 200 to 373.

Before:

Hbv DNA 170 million
As I said my Sgpt 200
Hbeag reactive

After 1 month
Hbv DNA 133,000
Hbeag reactive
Sgpt 373

My alt increasing is this normal?after 2 more months what will be next happen to my sgpt.please share with ur tdf experienced.

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Hepatitis B :: Viread Treatment

I have been diagnosed with Hep B. I was admitted to hospital with exceptional readings (ALT >4,000, bilirubin 180, all pho 162, gamma get 417, AST >2,500). I've been given various drips and the numbers are coming down. ALT has now halved. In addition to the drips I was also put on Viread.

My physician was concerned how my immune system was attacking the liver and between all treatments, in three days the readings are coming down. My jaundice is going and my urine now looking paler (almost normal).

Given the symptoms indicate a severe acute response to infection, does this suggest my body will put up a good fight to rid itself of the virus. Also, is there a risk Viread could actually lead to my body not developing the antibodies? I've read the following study, which suggests Viread can be highly effective in treating severe acute Hep B and also assist (or at least not inhibit) the development of antibodies.

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Hepatitis B :: Viread Results After One Month

I want to know..if continue taking this..viread.my liver is going to serious damage?.my lab result before taking viread.

Hbv DNA - 170 million
Sgpt - 200
Hbeag - reactive

After 1 one month of taking tdf.

Hbv DNA - 100,000 something..
Hbeag - reactive
Sgpt - 337

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What happens if I take brand and then switch to generic like a year later? Will the generic medicine do the same?

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When I first began treatment with pegasys in january 2014, GGT was 60 (normal max is 35), ASAT 51 (normal max 35), ALAT 76 (normal 10-40), LDH/Bili/CK all within normal range. With pegasys, a few months later down the line, the values continued to go higher. At their highest, GGT 223, ASAT 116, ALAT 156, LDH 274, Bili/CK remained within normal range.

At the beginning of the treatment, Hep B ie/ml  was 2400. Four months later, it became 2600.  When I was shifted to tenofovir/Viread three or months after beginning treatment since pegasys wasn't solving the issue, the ASAT, ALAT, LDH came back down to normal levels quite fast.  So I have been on viread ever since.

10 months after beginning treatment, Hep B ie/ml was down to 1800. In 2015, it was less than 150. Hep B Dna was undetected by May 2015.  I get regular blood tests every three months since the start of the treatment.  

Yesterday's blood test showed:   ASAT 36 (normal max 35), ALAT 38 (normal 40, but having checked past blood tests, it seems in the last few months it has been gaining one or two points steadily so this is worrying me), LDH and Bili are normal. The bad news: Heb B DNA detected...and IE/ml was a whopping 3400!!!! More than when I started started treatment!

The first thing I was asked was whether I missed a dose of viread. Answer is no. However, I have had incidents where I did forget to take it on time, but it has never exceeded 5 hours (still, I know, it's a huge gap). Not a lot of times, but I find that I am beating myself over this now, as it may be the reason I am having a viral overload and maybe made the virus resistant to viread.

Since taking viread, I have experienced and continue to experience extreme muscle pain (I ended up in the hospital once when diclofenac  failed me and I needed an extra morphine shot to get relief). I am continuously tired, some days it is a real struggle to move (feels like going through mud - heavy body, wanting to simply just crash on the floor). I have not had a pain free day in the last two years and worse, kidney stones! I am already prone to them, but I can't get over the suspicion that Viread has ensured I have a stone that needs to be taken out each year.

I've read that viread is one of the best treatment there is (hardly any side effects, probability of virus resistance low) so my latest blood test is worrying me no end. I am not due for another DNA test until 6 months later. I've also read that ASAT and ALAT values can increase and it's not necessarily liver related (I think my ongoing and increasing muscle pain is reflecting higher ASAT and ALAT values but who knows?!?).  

My doctor says that as long as those values remain within normal range and not in the hundreds, it should be ok. But there is this unspoken thought that I am in deep trouble if the DNA continues to manifest and my liver enzyme values continue to increase.  My liver scan in 2014 has me a point JUST before entering cirrhosis stage. I can't help but think I may have actually crossed that line already (the cassandra in me speaking) though I am assured that viread treatment tends to pull back the damage.

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I am genotype 1, had liver transplant in 2001, treated and relapsed after 72 weeks of Interferon and Riba in 2006/7.  Possible cirrhosis, as biopsy shows F1 and but Fibroscan shows 27 kPa.  Have controlled HE (Xifaxan) and some ascites on CT scan.  PCR at four weeks showed presence of virus at less than 43 (13 million in January).

Amazed at the improvements compared to the day I started treatment.
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ALT:  59/31
SGOT:  61/36
Albumin:  3.1/3.7
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Platelets:  126k/132k
HGB:  11.9/12.4
ALP:  273/196
GGT:  1283/543
INR: 1.0/1.1
Ammonia: 52/35
Creatinine: .8/.8

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