Hepatitis B :: 3 Months On Viread DNA Positive < 20 Iu/ml


Apr 18, 2016

I ve been on viread for 3 months. The latest hbv dna is positive <20 ıu/ml. Before viread I was on lamivudine and hbv dna was generally again positive <20 ıu/ml. I think it was 3 times undetectable at different times. Alt Ast normal afp normal. Do you think dna will be und next time? If it comes positive again what.  treatment or evaluation can you recommend ? I also started to take vit d3 daily 10 days ago.

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After 1month of viread, my alt increased from 200 to 373.

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My alt increasing is this normal?after 2 more months what will be next happen to my sgpt.please share with ur tdf experienced.

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My physician was concerned how my immune system was attacking the liver and between all treatments, in three days the readings are coming down. My jaundice is going and my urine now looking paler (almost normal).

Given the symptoms indicate a severe acute response to infection, does this suggest my body will put up a good fight to rid itself of the virus. Also, is there a risk Viread could actually lead to my body not developing the antibodies? I've read the following study, which suggests Viread can be highly effective in treating severe acute Hep B and also assist (or at least not inhibit) the development of antibodies.

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Hepatitis B :: Viread Results After One Month

I want to know..if continue taking this..viread.my liver is going to serious damage?.my lab result before taking viread.

Hbv DNA - 170 million
Sgpt - 200
Hbeag - reactive

After 1 one month of taking tdf.

Hbv DNA - 100,000 something..
Hbeag - reactive
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What happens if I take brand and then switch to generic like a year later? Will the generic medicine do the same?

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10 months after beginning treatment, Hep B ie/ml was down to 1800. In 2015, it was less than 150. Hep B Dna was undetected by May 2015.  I get regular blood tests every three months since the start of the treatment.  

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The first thing I was asked was whether I missed a dose of viread. Answer is no. However, I have had incidents where I did forget to take it on time, but it has never exceeded 5 hours (still, I know, it's a huge gap). Not a lot of times, but I find that I am beating myself over this now, as it may be the reason I am having a viral overload and maybe made the virus resistant to viread.

Since taking viread, I have experienced and continue to experience extreme muscle pain (I ended up in the hospital once when diclofenac  failed me and I needed an extra morphine shot to get relief). I am continuously tired, some days it is a real struggle to move (feels like going through mud - heavy body, wanting to simply just crash on the floor). I have not had a pain free day in the last two years and worse, kidney stones! I am already prone to them, but I can't get over the suspicion that Viread has ensured I have a stone that needs to be taken out each year.

I've read that viread is one of the best treatment there is (hardly any side effects, probability of virus resistance low) so my latest blood test is worrying me no end. I am not due for another DNA test until 6 months later. I've also read that ASAT and ALAT values can increase and it's not necessarily liver related (I think my ongoing and increasing muscle pain is reflecting higher ASAT and ALAT values but who knows?!?).  

My doctor says that as long as those values remain within normal range and not in the hundreds, it should be ok. But there is this unspoken thought that I am in deep trouble if the DNA continues to manifest and my liver enzyme values continue to increase.  My liver scan in 2014 has me a point JUST before entering cirrhosis stage. I can't help but think I may have actually crossed that line already (the cassandra in me speaking) though I am assured that viread treatment tends to pull back the damage.

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