Mirtazapine :: Ultra High Doses Work?


Dec 14, 2014

Is there anybody who finds that ultra high doses of mirtazapine worked better for them? In the past I have taken mirtazapine in doses 30 mg and it had worked for a while but then I have changed my meds (bad for me). The second time I have taken mirt 45 mg without success It's the best drug I have ever taken, but it's not working anymore. I have taken many of the drugs, like SSRIs, bupropion and others, but none of them worked like mirtazapine in the past. How do you think, is there any possibility that ultra high doses like 60-90 mg would be work better for me?

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I received the methotrexate shot on Thursday, and on Saturday morning I inserted 4 misoprostol pills vaginally. A few hours later, I got some pretty bad cramping (wouldn't call it severe, but definitely like a really bad period). A few hours later, they completely went away besides the occasional discomfort. I had no bleeding (or spotting, not a drop), so I went to bed hoping to wake up in a puddle of mess (never thought I'd HOPE for that). 
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I have had my thyroid function test done last week and the results have come back but I'm not being told what they are until I get it in writing. The endo wants my TSH to come back up to 2.5.

Symptoms I have:

Goitre (ultrasound says thyroid is swollen but no nodules)
Difficulty swallowing
Ongoing cough
Headaches
Joint pains
Dry eyes
Dry ears
Dry mouth
Constipation
Itchy feeling in throat (front of neck where thyroid is)
Hair loss
Heavy periods
Painful periods
Pale skin
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Fatigue
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Peeling nails

November 2015
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Serum Free T4 level: 19.8pmol/L (12.0 - 22.0)
Serum Free T3 level: 5.2pmol/L (3.90 - 6.70)

October 2015
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Serum Free T4 level: 20.5pmol/L (12.0 - 22.0)
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August 2015
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May 2015
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March 2015
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Despite my anxiety been kind of excessive at the moment, after a discussion with my GP, he was happy to let me begin tapering down the dose. The problem is with my anxiety I feel it mainly physically rather than mentally so it makes me a little oversensitive to any changes that take place in my body.

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I'm kind of freaked out a little because one of my fears that's arisen since the mirtazapine is the that i will develop random allergies and my brain is wondering if I've suddenly developed an allergy to my meds (ridiculous, I know!) The other thing is that the rest of my family has had either viral chest problems lately so maybe I've just picked up that and it's a coincidence? Or it could just be the anxiety.

I'm totally spinning myself in circles at the moment so any wise words are most welcome at this point. If I know it is just withdrawal and nothing that can actually hurt me then I'm fine with whatever effects it throws at me.

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Liver function test result are  ALT/SGPT = 16U/L, SGOT = 19U/L, alkaline phosphate = 114 U/L , i am vitamin D deficient. march 2016 current level of vitamin D(25-OH) =26ng/ml . i take 600000 IU two injections in 2013 when my level was 4ng/ml and then i take 200000 IU one capsule  in oct 2015 .
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I was initially on(30mg) for 8 weeks for depression and anxiety. And I did start to feel better, although the blurry vision and the derealisation side effects started to make me anxious again. I think the light head was the anxiety not the tablets.

Went back to work and made an appointment with the Doctor to see if there was another antidepressant with no side effects as I didn't think the Mirt was working.

He told me how to gradually come off the Mirtazapine and then to start Those days coming off the Mirtazapine were fine and the 3 days I took nothing I felt great again! Well what an awful reaction I had to the Citalopram ! Heart thumping, sickness, mind racing, pins and needles, total insomnia for 3 days and the anxiety attacks were awful! I actually phoned NHS Direct.

When I spoke to the Doctor , he said that I had a reaction and the tablets obviously didn't agree. In a knowing smile, he said that I should perhaps go back on the Mirt and that I came off them too quickly.

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