Difference Between Zocor And Zetia?


Aug 3, 2014

I’ve had problems with high cholesterol for years, but it wasn’t causing me any major issues until recently when I had to be hospitalized because one of my arteries was almost completely clogged. I’m waiting for the stent placement surgery and in the meantime I was given two medications that are supposed to lower my cholesterol: Zocor and Zetia.

Ever since I started taking them I feel more tired than usual and the nurse said that is relatively common side effect from Zocor, but I’m not really sure what is the difference between Zocor and Zetia and do i need both of them to lower my cholesterol?

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Switching From Zetia To Zocor

I was prescribed Zetia after my regular physical showed I have borderline high cholesterol and Zetia was supposed to bring it back down to normal range. However, that did not happen at all, in fact during the time I was on Zetia I had either the same cholesterol results or even an increase.

Now my physician wants to switch me to statin medication Zocor and to be honest I’m reluctant to start taking it mainly because all the experiences and warnings about statin side effects. Would an increased dose of Zetia be enough to prevent my physician from switching me to Zocor?

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Zocor And Zetia Comparison

I’m 52 year old male and I’ve considered myself to be pretty much healthy overall, never really needed to see my physician, but I had to get a general check up for work and the bloodwork showed my bad cholesterol levels were in high range. I was immediately given prescription for Zocor (generic simvastatin)

Despite feeling like I had a worst flu ever, with bone and muscle aches for the few months I was on Zocor, my cholesterol went down enough for me not to have to take Zocor anymore. But, my doctor is prescribing me different cholesterol lowering medication, Zetia and will it cause the same side effects as Zocor?

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Zocor And Zetia Together? Headaches, Constant Tiredness

I’ve been on Zocor (generic simvastatin) for years now and my cardiologist finally thinks it’s OK to lower my dosage from 80 mg to 60 and then hopefully 40 mg of Zocor. He probably wouldn’t have started tapering me down if it wasn’t for pretty bad side effects I was having from Zocor, including headaches, constant tiredness and pretty much feeling worn down for more than two years.

But, together with lowering my Zocor, he also added Zetia as another medication for lowering cholesterol and I’m wondering is it safe to take it at the same time with Zocor, given all the side effects I have?

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I was prescribed Zocor for high cholesterol I have for years. Before Zocor I was on Tricor and it didn’t help to lower my cholesterol at all, so my cardiologist switched me to statin because I was under a very realistic risk of having a heart attack. My cholesterol numbers did went a bit down, but it seems like they haven't gone down enough since at my last checkup my cardiologist added Zetia to my treatment with Zocor and Lisinopril I have to take for hypertension.

What worries me though is will Zetia make Zocor side effects worse and is this a good choice when there are other statin medications out there?

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I’m male, 42 years old and I’ve been having genetic problem with high levels of bad, LDL high cholesterol, in ranges between 250-270 over period of two years. The first statin medication I was prescribed was Crestor. It took me almost a year to convince my doctor that muscle and joint pain I’m experiencing because of Crestor are ruining my life completely.

So he took me off statins for a short period, just three months, and together with dietary changes, my LDL cholesterol levels were around 250. I was having a completely normal and healthy sex life. Then my doctor decided my levels are still too high and that I need another statin - Zocor  (simvastatin) and for the past six months I’ve been on Zocor, I’ve been having extreme erectile dysfunction.

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Even though I was aware of potential side effects statin medications might cause, mainly them causing muscle and joint pain, I had little choice but to start taking Zocor after I had heart attack. At that point, my bad cholesterol levels were through the roof and it’s still uncertain if I’ll have to have coronary artery stents placed or not.

Ever since I started Zocor I feel more tired than I ever was in my life. I have a feeling I could sleep all day, with barely any motivation to do anything. Could this tiredness be another side effect of statins?

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After this I decided to take the matter into my own hands and continue with healthy diet, exercise and no Zocor (but I do use red rice supplement instead) and finally my hair is not falling off any more.

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Is it possible that Zocor is contributing to my weight gain? And if that’s the case what can I do about it?

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My mom, now 65 years old, started experiencing problems with frequent urination and pain during urination. At first she thought it was just UTI and her doctor gave her antibiotics. However, it’s been 3 weeks after she finished her antibiotics and she still says she has problems with urination.
The only other medication she is taking for high cholesterol is Zocor and she’s been on it for years now, but is it possible that Zocor is causing my mom’s issues?

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