Pernicious Anaemia :: B12 - Low Cellular Levels, High Serum Levels After 5 Years Treatment

Mar 29, 2016

I found out I had a B12 deficiency 5 years ago.  My levels were very dangerously low at the cellular/functional level.  I was told I was near paralysis. Now, after 5 years, they are still low.  They have come up to almost borderline, but it still flags red on my tests.  My serum levels though are too high for the lab to measure! Its just not getting into my cells so it's not able to be used.  I do twice a week injections plus twice a month IV B12 and still it has taken my body 5 years just to go up a little bit. I feel the effects of the shot for about 15 hours barely then I just feel awful again, thankfully it's prescribed every 2 days.  But I don't want to do it every 2 days forever! 

In the beginning I was told it would take a month or two to get my body back to normal and then just a shot every few months for maintenance. My drs have not only increased my dose but also the frequency and STILL after all these years I'm deficient.  


View 2 Replies


Thyroid Disorders :: T4 Levels And Cortisol Levels Low?

Why are my T4 levels and Cortisol levels low?

I have been having symptoms of depression, fatigue, low libido and weight gain over the last few years. I am 50 and have gone through menopause. My latest lab results are:

TSH  1.064   (0.358-3.74)
Free T4   9.7    (9.8-18.8)
ferritin  16   (3-105)
B12   498   (156-672)
Cortisol  28   (155-570)
RBC's    normal

I am not taking any thyroid meds......only nexium and Cymbalta.

What do these results mean?  Can someone give me some insight into the results please?

View 1 Replies

Angina Due To High Cholesterol Levels

Hubby has had a few chest pains, so we went to the GP where he had an ECG, all pretty normal but we got referred to the hospital anyway, where hubby had another ECG, blood test and we were told that he may have Angina also his Cholesterol levels were high? i am puzzled as to why, we eat a healthy diet, we eat lean proteins, no fats, fruit and veg, we never eat fast foods and all our foods are home cooking and no fats, hubby doesn't drink or smoke, so why? we can't eat any better also he can't exercise as he has chronic Degenerative disc problems which makes him very immobile!!!! so can anyone tell me ,what i do now, how can i lower the cholesterol levels, hubby is a bit overweight but only due to his back problem, not food! he has to go for an Angiogram in a few weeks.

View 3 Replies

High CRP And ESR Levels - Means Inflammation?

I got bloodwork done at the rheumatologist in March and the CRP and ESR levels were high which means inflammation. I got more done in May and its still high. My dr. says there's nothing i can do about it because the location can't be indicated for the inflammation. what do i do now? I need to lose about 30 lbs do you think this will help?

View 1 Replies

Pregnancy :: High Levels Of Protein In My Urine

I am 27 weeks pregnant with my third child. I had to have a urinalysis done yesterday and it showed that I have high levels of protein in my urine. I don't see my doctor for two weeks. My pregnancy so far has been pretty smooth.  I have pcos and have had a cyst but that's it. Has anyone ever had high protein in your urine and if so what was the outcome?

View 2 Replies

Urology :: High Levels Of Protein In Urine

I have increased level of proteins in urine. My doctor said that I need to collect more urine and bring to examination to determine what kind of urinary disorder is that. What can cause increased level of proteins in urine?

View 1 Replies

Pituitary Disorders :: High Prolactin Levels

I found out about 6 months ago that I have high prolactin levels. They have put me on 2 different medications to reduce the levels. The first one made me sick so they lowered the dose. I am still experiencing abdominal cramps when I take them and my doctor doesn't seem to be concerned about it.

View 1 Replies

High Sodium Levels And Addison's Disease?

Curious if anyone knows what it means to have high sodium levels and Addison's disease? My sodium levels came back at 238 I've had more testing done but this one was the more extreme in numbers.

Anyone else have high sodium results?

View 9 Replies

Adrenal Insufficiency :: How High Cortisol Levels Can Go?

How high do very high cortisol numbers go?

View 1 Replies

PCOS :: Female With High Levels Of Testosterone

I've recently had a blood test for testosterone and I've been given a high reading of 2.4 but could anyone tell me what an average reading is? I'm 25 female and have pcos.

View 1 Replies

High Testosterone And Prolactin Levels At The Same Time?

What would cause elevated Testosterone(1028.53 ng/dL) and elevated Prolactin(26.13 ng/mL)levels at the same time? I have normal Total and Free PSA levels. My Thyroid function tests (TSH,Free T4 and Total T4) are normal. Vitamin D is normal, CEA is normal. I am a healthy 56 years old. I take no medications, drugs or alcohol. Do you have any idea what would cause this?

View 1 Replies

Kidney :: High Levels Of Protein (Albumin) In The Urine

My Uncle's wife had a kidney transplant last year. With recent medical checks, the doctor found high level of the protein (albumin) in her urine. Do any of you have an idea to what kind of medications she should stick to?

View 1 Replies

Pituitary Disorders :: High Prolactin But Normal Testosterone Levels?

I am a 27 year old male. For some time I've shown symptoms of a lack of sex drive and erectile dysfunction but as I suffer from anxiety always attributed it as the cause. I had some blood tests done privately and my results showed a slightly raised prolactin level but my testosterone seems average.

TSH 0.70 mIU/L (0.27 - 4.2) 

Prolactin 397 mIU/L (86 - 324) 

Testosterone 21.3 nmol/L (7.6 - 31.4) 

SHBG 35 nmol/L (16 - 55) 

The results seem to suggest Prolactinoma but a common side effect is low testosterone where my results prove otherwise. I'm afraid if I speak to my doctor he will tell me it is all in my head so I'm trying to make some sense of the results.

I guess the question I'm asking is is it possible to have raised Prolactin/Prolactinoma and normal looking testosterone levels? 

Should I speak to my doctor anyway?  

View 2 Replies

Pernicious Anaemia :: B12 Tablets In Between Injections ?

my son was diagnosed with B12 a year ago he got the 6 booster jabs last September he had been getting sore heads that were lasting up to 8 weeks his joints ache his shoulders and neck are really sore he was getting ear infections had 10 in last 6 months pins and needles in his hands and feet he is sleeping about 15 to 18 hours a day they started to give him 3 monthly jabs and after 6 month put him on monthly also done a blood test went back to get his second monthly jab but said his b12 levels were normal so put him back to 3 monthly but he could hardly get out of bed they have now put him back to monthly jabs which are only lasting a week if that asked if they could be given weekly the doctor said he would not be happy giving the jabs sooner he got his last jab on the 17 sep and its only lasted till yesterday the are treating him for chronic migraines and now telling me they think it is ME I am sick getting put of by doctors as my son has no life now and i was wondering if I could give him tablets in between jobs because when he first gets his b12 jabs the symptoms all disappear and he gets a week of feeling a lot better but they won't listen

View 1 Replies

Pernicious Anaemia :: What Are B12 Side Effects?

I have found reading the posts about PA very helpful, i was diagnosed early last year with PA and have injections every 3 months they have helped enormously with my symptoms, please could any one tell me about the side effects of the B12 injection, i have had various syptoms which i have just put down to the whole PA thing, but would like to know....

View 1 Replies

Pernicious Anaemia :: B12 Injections And Blood Donation Possible?

I have only recently started having the B12 injections. Does anyone know if you can still give blood? I used to be a regular donor but now I'm not sure if I can still give?

View 2 Replies

Pernicious Anaemia :: What Size Needles For Self Inject B12 Injections?

I've decided that I have no other choice than to self-inject B12.  I am older and don't have the same muscle tone that I used to have.  I will be injecting into my thigh muscle.  What would be the best sized needle for this?  Would a one inch needle be ok?  Anything longer might be too long if my muscles aren't what they used to be.  And what guage?

View 1 Replies

Pernicious Anaemia :: Intrinsic Factor - B12 - 6 Injections Didn't Help

I was diagnosed with low B12 levels and further tests revealed that I had intrinsic factor.

I was given the 6 injection course and was told I would have another in 12 weeks then again and then blood tested again. 6 weeks since my last injection and my symptoms are back. Feeling vague, tired, lethargic, irritated etc. How can it be that I have intrinsic factor but obviously have low B12?

is it likely something else is going on? - any ideas/suggestions?

View 3 Replies

Pernicious Anaemia :: Copper Deficiency - Outstanding Neurological Symptoms

I was diagnosed with copper deficiency a few months ago and sent for further investigations prior to treatment. As all scans, eye tests and liver functions were fine and no signs of copper storage or damage anywhere else as might explain the deficiency in my blood, so they have now decided that I am not deficient after all and I have not been treated.

These were my results which are all pretty low within the normal ranges (in brackets):

Copper 9.3 umol/L (normal is 12.0 - 20.0)

Free Copper <1% (<25%)

Ceruloplasmin 0.20 g/L (0.20 - 0.40)

I also have Pernicious Anaemia (B12 deficiency) and the two conditions often appear together and have similar symptoms. I have very regular B12 injections so I am happy that is under control but as there are still outstanding neurological symptoms, I am wondering if this is due to the low copper levels?

Has anybody else had similar results, please?

View 1 Replies

Cholesterol Levels :: HDL Is 0.99 - Isn't It Low?

am in the UK so the measurement system is different (mmol)

My TChol is 3.17. HDL is .99 and the ratio is 3.2. However, no LDL was done. I am told by my GP that there's no problem. Everything is fine and there's no need for a LDL test.

What do you think? Isn't the HDL a bit low?

I am male aged 68.

View 3 Replies

Gay Look Due To Low Testosterone Levels

I am worried I have low testosterone levels. I am 16, and have a very high-pitched voice, hourglass figure, little body hair, little pubic hair, little underarm hair and very little muscle.

I am really worried, as this will affect me long-term and it is really embarrassing.

I know many people might say "maybe you're gay" but i don't think deep down i am.

View 1 Replies

Copyrights 2005-15, All rights reserved