Progesterone To Help Regulate Sphincter Of Oddi Function?


Oct 11, 2013

Does anyone out here have any experience with using progesterone to help regulate the function of the Sphincter of Oddi?

My history: I am a healthy and active 132lb, 42 year old female, but I have been having pain in my upper right shoulder, neck and collarbone for three years now that has really curtailed my life and work. I have tried massage, acupuncture, physical therapy, drugs, strength training, chiro, all with no results. Recently a chiro noticed that my gallbladder area was tender and mentioned that gallbladder problems can refer pain up to the right shoulder area through the phrenic nerve. When I started tracking my pain and food I did notice a connection with pain in my shoulder and my right lower ribs as well (which I had been hiding with lots of ibuprofen). An ultrasound, blood work, and HIDA came back normal (at least that's how the doc reads it), but I'm still having pains when I eat oily foods. So now I am thinking I might have problems with the sphincter and with bile backing up creating pressure on the phrenic nerve. Another symptom is that I am now also having pains on my left side which could be the pancreas being impacted, which shares the common duct and sphincter.

So my question stems from the fact that I had a hysterectomy several years back and have only been on estrogen replacement. I've recently found out that progesterone is important for relaxing the Sphincter of Oddi muscles as well as gallbladder function (as well as many other things). When my nutritionist suggested a few months back to use Progonol, a progesterone cream, it did have a positive effect on the pain within two weeks, but it also caused acid reflux (it also loosens the valve between the esophagus and the stomach), so I had to stop taking it and now we are trying to figure out the best way to introduce it back into my body.

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I had my gallbladder removed laparascopically 2.5 years ago. Have had some issues with diarrhea but nothing else. About 3 weeks ago I was diagnosed by my PCP based on my symptoms with gastritis due to Nsaid overuse. Have been on a PPI and Carafate. Not improving at all, in fact getting worse. My ALT liver enzyme was slightly high but otherwise the rest of the blood work was normal.

Went back to see my PCP today and she brought up the subject, based on my symptoms, of possible Sphincter of Oddi malfunction. My symptoms are RUQ pain that comes and goes, yellow stool, stomach bloating and nagging upper back pain between shoulder blades. I have an ultrasound on Friday. After reading about SOD (shudder) I think this might be just the beginning of the saga if I do indeed have it.

Do any of you dear readers have any experience or knowledge in this area?

It is a good thing I am retired because I have been basically sacked out on the couch. I think it would be impossible to work with the degree of discomfort I am having.

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My SOD had two pain styles. My daily pain is very successfully managed (99% pain free days) using 30 mg amitriptyline each night and 10mg Buscopan 3xdaily. Before drugs my daily pain was so bad that I was hardly eating - not a long term strategy.

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