Severe Rage - Switching From Sertraline To Duloxetine!


Jan 29, 2016

I recently asked advice as changed to duloxetine from sertraline. I am experiencing severe RAGE since changing my medication and don't know what to do about this!  Have any of you suffered with severe rage, I have tried many antidepressants over the years but have not experienced anything like this!  Feeling really upset and desperate now, also has done nothing to help with my depression in fact it is worse than ever.

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Weight Gain Due To Cymbalta (duloxetine) Switching To Venlafaxine?

I didn't do well on cymbalta (duloxetine). Initially, I started to feel better, but after a couple of months I started to feel depressed again. I also gained weight.

When I started to withdraw from cymbalta, my weight started to creep up even more. I've always been 7 st, and now I'm 8 st and 5 lbs.

My Psychiatrist wants to start me on venlafaxine, but I'm so worried that I'm going to end up gaining more weight. In the past, I've been on Citalopram and Fluoxetine. None of those worked for me, that's why my Psychiatrist tried the SNRI.

I feel like a complete failure, and am believing I'm unhelpable. Weight gain is a big issue for me, I don't like not being in control.

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Switching From Fluoxetine To Duloxetine (appetite And Weight Issues)

Fluoxetine not working well been on it 13 weeks tired all the time. Motivation minus a hundred and thoughts of wanting to die are more often than ever

Saw specialist thinks Duloxetine would be good for me anyone tried it? Lost all my appetite on fluoxetine but was glad needed to lose grieving weight and now worried new pill will make me want to eat!

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Sertraline :: Switching From Prozac To Zoloft

I've been on Prozac about a week and a half and it isn't agreeing with me. My anxiety is the worse at ever been and I can't leave the house. My doctor wants to switch me to Zoloft. The main reason her and I agreed to try Prozac first was because I'm terrified of gaining weight. I'm 23 and already have a major weight issue. I took lexapro as a teen and gained tons of weight. So, I am wondering, does anyone notice any significant weight changes on Zoloft? Also, how do people find Zoloft to help with anxiety?

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Cymbalta (Duloxetine) :: Severe Hand Tremors

Has anyone had this happen?  I had gone up from the 20mg dose to the 40mg dose and was doing better.  Less depression and the goal was to ease my fibro pain (I currently take Gabapentin and Tramadol) and eventually stop taking Tramadol.  I suddenly started shaking.  I had muscle jumps (can't think of another way to describe it) in my  legs and I literally shook so bad I couldn't turn pages on my Kindle without trying a few times.  It was disturbing.

The doctor called me back said to go back to the 20mb dose.  I continued to shake...but it lessened.  I am now going off it by taking it every other day (20mb) and can't get the Dr. to return my call.

I have tried all the Fibro drugs.  Lyrica didn't work.  Savella caused bad rapid h/b.  Effexor caused muscle jumps in my legs too (but not hand shaking).

If I continued to take it would the hand tremors go away?  No one can answer that.  Pain is worse since I have eased off so it was actually working.  I want to continue if it will lesson, but I don't know if it will.

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Severe Depression And Anxiety - Sertraline , Mirtazapine And Now Venlafaxine

i had an assessment after struggling with depression and anxiety for yrs , finally went back on ADs just before xmas, after trying sertraline , mirtazapine i'm now on venlafaxine , over the last 6 weeks it's increased to 225mg. My assessment came out with a high score in the range of severe depression and anxiety . I have previously had time off work due to this , however i'm doing my best to stay at work as i'm only p/t and work with some fab ppl . However i feel like everything is getting too much again , i had gp last wk and i just said all was ok , it wasn't but my child was in the room so couldn't speak ,  Also had my first cbt session today a ' panic workshop ' one , even with them discussing panic attacks makes me feel edgy and haven't been able to shake the feeling off since , i feel like i'm fighting a losing battle and just cant cope. So much has gone on recently , 7yr relationship breakdown / ended . Problems with child behavior , time off work last yr for an op that didn't go to plan ( should of been day surgery - 3 days in hospital , 7.5 wks off work ) moving house , family disagreements ( not to do with me but get dragged in ) Just so much - i don't know what to do , i feel like a whinge if i go back to gp again.

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Sertraline :: Sertraline 50mg To 25mg But Still Side Effects

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Sertraline :: Advice On Stopping Sertraline

I had some terrible problems last november stopping venlafaxine to start sertraline.  I realised I have tried over 6 different meds and have decided to get back to the start and take none.  I have been to a doctor today who was not very helpful and as I have never been given the right advice about cross tapering I am not confident about stopping.  I started with 50mg, 1 december 2014, in mid January increased to 100mg and to be honest things are worse in the way I feel.  No libido (I am a happily married 46 year old woman who used to enjoy my husbands attention), No motivation, No sense of enjoyment in anything, overeating, overspending and little or no self worth.  I have been told stop 100mg and take 50mg for 4 weeks and then review.  I am thinking maybe 75mg for a week, then 50mg for a week, then 25mg for a week then nothing....  Any ideas?  I have been on one antidepressant or another since 2009. 

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Duloxetine :: Not All Bad

I have been on Cymbalta/Duloxetine for over two years now after having reactions to Sertraline etc. This was at 60mg and to be truthful it didn't do a lot. About 8 weeks ago this was doubled to 120 mg and this has increased my movement, mood and power to stay awake. It has also reduced my tremor.

I noticed I seem to be the only person on this level.

I am being queried following abnormal PET scan that indicated possible Parkinson's but DaT scan negative so not that. Also have mild Ischaemic changes in frontal lobes of the brain. All still under investigation. Has anyone else been prescribed this for same or similar problems?

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Duloxetine :: Having Headaches

Been on Duloxetine 30mg for 5 days now - having headaches -Will they go away ? - I want to feel myself again any idea how long it takes for the tablets to kick in. I feel ok for a little while in the morning then i feel poorly again have to lay down and take co- codamol to take the headaches away - Can anyone give me any information of their experiences please -

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Fluoxetine To Duloxetine?

I hope you're all making progress and feeling better.

I'll cut a long story short - I was taken off fluoxetine because I went really downhill. My Psychiatrist has given me Duloxetine which is an SSNI. It works on serotonin and nor.....?? I can't remember the spelling.

I'm reluctant to take it right now because I went on the forum for Duloxetine and haven't found many posts at all!! I think there are about 4-5 posts!!

Have any of you had this medication before? Any advice about what I should do? I don't mind the side effects, I'm just worried that my head's going to get messed up further.

Apart from all that, I feel a bit better having posted on here this morning cos I've not been on the forum for a while.

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Mirtazapine And Duloxetine

Psychiatrist has upped my mirtazapine from 15mg to 30mg and is about to start me on Duloxetine as a combination, is anyone else in this combo and have any advice?

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Duloxetine Can Cause Liver Problems?

I have been prescribed this drug. Is this drug safe as it says it can cause liver problems

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Depression :: Duloxetine And Nightmares

I've been on duloxetine for about 18 months now (I think, my memory's awful) and have always had disturbed dreams and nightmares while I've been on it. Originally I was taking zolpidem 10 mg and Quetiapine 100mg at night but I've taken myself off of those over the last few months. The nightmares have gotten worse though, they're incredibly realistic. Last night I dreamt that I was drinking and I woke up heaving and with an intense headache like I was hungover. Then I managed to go back to sleep and after dreaming that I was back at my parents house and arguing with them, I woke up in such a state and my anxiety was so high I couldn't even move, I was struggling to breathe and scared because I was struggling to differentiate between what was real and what was a dream. I never wake up feeling rested and am constantly tired and yawning throughout the day, I've also been suffering more with headaches. Has anyone else on duloxetine had issues with sleep and dreams and is there anything that helps?

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Experiencing Bad Duloxetine Withdrawal

just wondered if anyone else is experiencing the hell that is duloxetine withdrawal?

This is my 5th day of being off the duloxetine all together. Im now on Mirtazapine. I dont know if what Im experiencing is the duloxetine withdrawal or the side effects of Mirtazapine :?

I am so spaced out its unreal. I get brain shocks constantly that really take your breath away and literally stop you from doing anything. I go to get dressed and zap, there it is. I bend down to pick up my jeans, and zap. Turn round to look at something and zap. I ache from limb to limb like a 90 year old with arthritis!! Im exhausted physically and mentally and I am just unable to do anything. I haven't been out of the house for 8 days, and haven't got dressed for 6!

I'm so sick of this med roundabout. I've been ill for little over a year now and have sampled 8 delightful anti deps, 3 anti psych and 2 relaxants. I feel like a junkie. Every time I move onto a new tablet, I have to go through some sort of withdrawal. These meds are supposed to be non addictive, but I'm beginning to think otherwise. They said that Valium wasn't addictive when that came out, now look.

I'm just so sick and tired of this whole roller coaster. As if it's not bad enough being depressed and out of your mind with worry and fear in the first place, but to then take tablets that are supposed to help the situation, but actually just add to your problems!

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Duloxetine :: Dilated Pupils

Right i decided to wait for stag dos to be finished. Now on day 3 of duloxetine. I have nausea and very tired effects kicking in alongside dilated pupils. Does this subside after time, i never felt this bad on any antidepressants.

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Been given duloxetine to to try for my depression and wondered if anybody has been using it what your reviews are on it 

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Duloxetine (Cymbalta) For Pain ? Or Antidepressant?

First of all I am not diabetic but I do need help on the above tablet Duloxetine (Cymbalta) which I believe is given to diabetics for pain relief (or so my doc tells me).  I have Cervical spondylosis which gives me extreme pain and for which I take 30 tabs daily plus Morphine and liquid Morphine.   Doc has prescribed Duloxetine which is an antidepressant but which I believe also helps pain. Can anyone on this site who is diabetic tell me about Duloxetine or have they taken it and has it helped with pain?   I am afraid to start taking it as it does not have good reviews and is used mainly as an antidepressant. There appear to be too many side effects, some of which I have already from morphine and it appears to be difficult to come off.   If anyone can comment and help me with this I would be really grateful.   I suffer chronic pain 24/7 and my meds at the moment are having little effect on controlling the pain.  They just keep increasing morphine dose which I am a little afraid of.   Does Duloxetine really work in controlling pain?

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Cymbalta To Generic Duloxetine - Crashed

I have been recently changed from Cymbalta to generic duloxetine.  Whilst on Cymbalta, I was able to cut down from 120 mgs daily to 90 mgs daily.

Now I have had to go back to 120 mgs as I have a terrible depressive crash very close to 3 pm every day.  I have always taken my full dose in one dose in the morning.  Now I am splitting it to avoid the 3 pm crash.  I asked my psychiatrist for Cymbalta specifically as in the US it is prescribed for fibromyalgia which I also have.  I had seemed to be improving on that front too and was hoping to get back to part time work but I have been more or less bedridden for the last two weeks.  Anybody else had problems with the switch over?

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Fibromyalgia Syndrome :: Duloxetine Experiences?

i am really struggling with my fibro. The doc has told me to persevere with this tablet. He has also gave me an anti sickness tablet. I would like to know people's experiences with this please.

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Duloxetine :: Sweating And Yawning Fits

I started on 30mg of duloxetine (cymbalta) about 3 weeks ago. I was prescribed it for severe lower back pain. And mood swings. I was previously on sertraline. But I was getting severe sweats. Constant yawning fits. And feeling hyper. Anyway since being on duloxetine. My sex drive has gone. I have also been having light bleeding for 3 weeks. Has anyone else experienced this. Drs said its a coincidence. But iv never ever had bleeding for more than 5 days. I have stopped taking it for 2 days now. I'm feeling very tired. My back pain is coming back.

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